Fish research aids Utah cancer study
By Lois M. Collins
Deseret Morning News
Research on zebra fish has helped Huntsman Cancer Institute scientists identify a target that might one day lead to prevention or treatment of colon cancer — the No. 2 cause of cancer deaths in the United States.
The findings, published in the current online Journal of Biological Chemistry, indicate that a process the researchers used to rescue zebra fish from abnormal intestinal development may also head off a series of events known to be involved in development of colon cancer in people.
The scientists "knocked out" the molecule C-Terminal Binding Protein (CTBP) to save the zebra fish from a mutation in the adenomatous polyposis coli (APC) gene. Mutations in the same gene in humans lead to colon polyps, which are the precursor to colon cancer. The APC mutations are involved in 85 percent of human colon cancers, according to David A. Jones, a University of Utah associate professor of oncological sciences and leader of the study.story continued
Deseret Morning News
Research on zebra fish has helped Huntsman Cancer Institute scientists identify a target that might one day lead to prevention or treatment of colon cancer — the No. 2 cause of cancer deaths in the United States.
The findings, published in the current online Journal of Biological Chemistry, indicate that a process the researchers used to rescue zebra fish from abnormal intestinal development may also head off a series of events known to be involved in development of colon cancer in people.
The scientists "knocked out" the molecule C-Terminal Binding Protein (CTBP) to save the zebra fish from a mutation in the adenomatous polyposis coli (APC) gene. Mutations in the same gene in humans lead to colon polyps, which are the precursor to colon cancer. The APC mutations are involved in 85 percent of human colon cancers, according to David A. Jones, a University of Utah associate professor of oncological sciences and leader of the study.story continued
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